Ÿ R¶•¨Ž¿‚ðŠÜ‚ÞPDBƒf[ƒ^iJmol”Łj Ÿ
¨ Chime”Å b R¶•¨Ž¿ƒf[ƒ^Wƒƒjƒ…[ ©
¦‰Šú•\Ž¦‚̓oƒ“ƒRƒ}ƒCƒVƒ“‚ðŠÜ‚Þ1pnv‚ÌChain B

PDB & PDBsumƒf[ƒ^R¶•¨Ž¿i‰p–¼CŒn“j
œƒÀ-ƒ‰ƒNƒ^ƒ€Œn
1fxv‚ÌChain B@@“¯PDBsumƒf[ƒ^1fxv_PNN@¨ ƒyƒjƒVƒŠƒ“G‚ðŠÜ‚ސ¶‘Ì•ªŽq‚ÌSITE—á ƒyƒjƒVƒŠƒ“ipenicillin GCƒÀ-ƒ‰ƒNƒ^ƒ€Œn^ƒyƒjƒVƒŠƒ“Œnj
3huo@@“¯PDBsumƒf[ƒ^3huo_PNN
“¯ã
3kp2@“¯PDBsumƒf[ƒ^3kp2_PNN
“¯ã
1uof@¦FeŠÜ‚ށ@“¯PDBsumƒf[ƒ^1uof_PNN
“¯ã
3ndg@@“¯PDBsumƒf[ƒ^3ndg_7EP@¦ƒƒ`ƒVƒŠƒ“‚Íbound formiŒ‹‡Œ^j ƒƒ`ƒVƒŠƒ“imethicillinCƒÀ-ƒ‰ƒNƒ^ƒ€Œn^ƒyƒjƒVƒŠƒ“Œnj
4fh2@@“¯PDBsumƒf[ƒ^4fh2_0RN ƒXƒ‹ƒoƒNƒ^ƒ€isulbactamCƒÀ-ƒ‰ƒNƒ^ƒ€Œnj
œƒAƒ~ƒmƒOƒŠƒRƒVƒhŒn
1m4i‚ÌChain A@“¯PDBsumƒf[ƒ^1m4i_KAN ƒJƒiƒ}ƒCƒVƒ“ikanamycin ACƒAƒ~ƒmƒOƒŠƒRƒVƒhŒnj
1byj@“¯PDBsumƒf[ƒ^1byj_GE1-GE2-GE3 ƒQƒ“ƒ^ƒ}ƒCƒVƒ“igentamicinCƒAƒ~ƒmƒOƒŠƒRƒVƒhŒnj
1ei2‚ÌModel 1@“¯PDBsumƒf[ƒ^1ei2_NMY ƒlƒIƒ}ƒCƒVƒ“ineomycin BCƒAƒ~ƒmƒOƒŠƒRƒVƒhŒnj
œƒAƒ~ƒmƒkƒNƒŒƒIƒVƒhŒn
5nc5@PUYipuromycinj‘I‘ð@¨ JmolƒgƒsƒbƒN ƒsƒ…[ƒƒ}ƒCƒVƒ“ipuromycinCƒAƒ~ƒmƒkƒNƒŒƒIƒVƒhŒnj
œƒIƒLƒTƒ]ƒŠƒWƒmƒ“Œn
4k7q‚Ì3—ʑ́iChain A~3j@“¯PDBsumƒf[ƒ^4k7q_ZLD ƒŠƒlƒ]ƒŠƒhilinezolidCƒIƒLƒTƒ]ƒŠƒWƒmƒ“Œnj
4wfa‚ÌChain X@ZLDilinezolidj‘I‘ð s’F–ñ3MBt
“¯ã
œƒJƒ‹ƒoƒyƒlƒ€Œn
1ll5‚ÌChain A@“¯PDBsumƒf[ƒ^1ll5_IM2@¦ƒCƒ~ƒyƒlƒ€‚Íopen form ƒCƒ~ƒyƒlƒ€iimipenemqopen formrCƒJƒ‹ƒoƒyƒlƒ€Œnj
3bfg‚ÌChain A@“¯PDBsumƒf[ƒ^3bfg_MER@¦ƒƒƒyƒlƒ€‚Íbound formiŒ‹‡Œ^j@¨ JmolƒgƒsƒbƒN ƒƒƒyƒlƒ€imeropenemCƒJƒ‹ƒoƒyƒlƒ€Œnj
œƒLƒmƒƒ“Œn^ƒjƒ…[ƒLƒmƒƒ“Œn
ƒLƒmƒƒ“ŒnŽQlƒf[ƒ^ 1kse ƒjƒ…[ƒLƒmƒƒ“Œn‚Ì—áGƒVƒvƒƒtƒƒLƒTƒVƒ“iciprofloxacinj
œƒOƒŠƒRƒyƒvƒ`ƒhŒn
1pnv‚ÌChain B@“¯PDBsumƒf[ƒ^1pnv_VAN ƒoƒ“ƒRƒ}ƒCƒVƒ“ivancomycinCƒOƒŠƒRƒyƒvƒ`ƒhŒnj
œƒNƒƒ‰ƒ€ƒtƒFƒjƒR[ƒ‹Œn
1cla@“¯PDBsumƒf[ƒ^1cla_CLM ƒNƒƒ‰ƒ€ƒtƒFƒjƒR[ƒ‹ichloramphenicolCƒNƒƒ‰ƒ€ƒtƒFƒjƒR[ƒ‹Œnj
œƒPƒgƒ‰ƒCƒhŒn
s —ª tiƒIƒŠƒWƒiƒ‹1p9xj s’F–ñ4MBt@@“¯PDBsumƒf[ƒ^1p9x_TEL ƒeƒŠƒXƒƒ}ƒCƒVƒ“itelithromycinCƒPƒgƒ‰ƒCƒhŒnj
œƒXƒgƒŒƒvƒgƒOƒ‰ƒ~ƒ“Œn
2z2p@“¯PDBsumƒf[ƒ^2z2p_MHW-THR-DBB-PRO-MHU-MHV-004@MHW-THR-DBB-PRO-MHU-MHV-004{Mg‘I‘ð@DOLidalfopristinj‘I‘ð@“¯PDBsumƒf[ƒ^2z2p_DOL ƒLƒkƒvƒŠƒXƒ`ƒ“iquinupristinCƒXƒgƒŒƒvƒgƒOƒ‰ƒ~ƒ“ŒnGPDBƒf[ƒ^‚ɂ̓_ƒ‹ƒzƒvƒŠƒXƒ`ƒ“qdalfopristinrŠÜ‚ށj
1mrl‚ÌChain A@“¯PDBsumƒf[ƒ^1mrl_DOL ƒ_ƒ‹ƒzƒvƒŠƒXƒ`ƒ“idalfopristinCƒXƒgƒŒƒvƒgƒOƒ‰ƒ~ƒ“Œnj
œƒZƒtƒFƒ€Œn
4kou@C04icefiximej‘I‘ð@“¯PDBsumƒf[ƒ^4kou_C04icefiximeG—°Ž_ƒCƒIƒ“‚Æ1,2-ethanediolŠÜ‚ށj ƒZƒtƒBƒLƒVƒ€icefiximeCƒZƒtƒFƒ€Œn^‘æ3¢‘ãƒZƒtƒ@ƒƒXƒ|ƒŠƒ“j@¨ JmolƒgƒsƒbƒN
œƒeƒgƒ‰ƒTƒCƒNƒŠƒ“Œn
4v2g@CTCichlortetracyclinej‘I‘ð@“¯PDBsumƒf[ƒ^4v2g_CTCichlortetracyclineGMgŠÜ‚ށj@“¯4v2g_ITCiisochlortetracyclineGƒCƒ\ƒNƒƒ‹ƒeƒgƒ‰ƒTƒCƒNƒŠƒ“j ƒNƒƒ‹ƒeƒgƒ‰ƒTƒCƒNƒŠƒ“ichlortetracyclineCƒeƒgƒ‰ƒTƒCƒNƒŠƒ“Œnj
3egz‚Ì8—ʑ́iChain AEB~4j@“¯PDBsumƒf[ƒ^3egz_CTC
“¯ã
œƒ}ƒNƒƒ‰ƒCƒhŒn
1m1k‚ÌChain A s’F–ñ3MBt@@¦PDBsumƒf[ƒ^‚ɂ̓ŠƒKƒ“ƒh‚Ì‚Ý ƒAƒWƒXƒƒ}ƒCƒVƒ“iazithromycinCƒ}ƒNƒƒ‰ƒCƒhŒnj
1nwy‚ÌChain CEQEZ sƒ¿’Y‘f‚̂݁t@¦PDBsumƒf[ƒ^‚ɂ̓ŠƒKƒ“ƒh‚Ì‚Ý
“¯ã
3aoc@“¯PDBsumƒf[ƒ^3aoc_ERY@¨ JmolƒgƒsƒbƒN[1]E[2]i•Êƒf[ƒ^j ƒGƒŠƒXƒƒ}ƒCƒVƒ“ierythromycinCƒ}ƒNƒƒ‰ƒCƒhŒnj
ƒGƒŠƒXƒƒ}ƒCƒVƒ“ŽQlƒf[ƒ^ 1oxa
@i‘O‹ì‘Ì‚Ì6-deoxyerythronolide B ŠÜ‚ށj
“¯ã
œƒŠƒ“ƒRƒ}ƒCƒVƒ“Œn
4wh5‚ÌChain A@3QBilincomycinj‘I‘ð@“¯PDBsumƒf[ƒ^4wh5_3QB ƒŠƒ“ƒRƒ}ƒCƒVƒ“ilincomycinCƒŠƒ“ƒRƒ}ƒCƒVƒ“ŒnGMgŠÜ‚ށj
œ‚»‚Ì‘¼i–¢•ª—ށCV‹KR¶•¨Ž¿‚⓯Œó•â‚Ȃǁj
2gfx*@“¯PDBsumƒf[ƒ^2gfx_PMN ƒvƒ‰ƒeƒ“ƒVƒ}ƒCƒVƒ“iplatensimycinCV‹KR¶•¨Ž¿Œó•âj
5jnq@TUMitunicamycinj‘I‘ð@“¯PDBsumƒf[ƒ^5jnq_TUM ƒ`ƒ…ƒjƒJƒ}ƒCƒVƒ“itunicamycinG“œ½‡¬‘jŠQ–òj@c•ªŽq•\Ž¦—ª
5uhg@“¯PDBsumƒf[ƒ^5uhg_RFP@¨ JmolƒgƒsƒbƒN ƒŠƒtƒ@ƒ“ƒsƒVƒ“irifampicinGƒŠƒtƒ@ƒ“ƒsƒ“ rifampinCRNA‡¬‘jŠQ‚É‚æ‚éRŒ‹Šjì—p‚Ȃǁj
¡‚»‚Ì‘¼
1dsr‚ÌModel 1@[Peptide Antibiotic]
1mqz‚ÌModel 1@[Lantibiotic]
1o83‚ÌChain BED*@[Peptide Antibiotic]


ƒoƒbƒNƒ{[ƒ“@“ñŽŸ\‘¢ b DNA/RNAiATGCUCbackbonej
‘S‘I‘ð@ƒ^ƒ“ƒpƒNŽ¿‘I‘ð@DNA/RNA‘I‘ð@“¯backbone‘I‘ð@ƒŠƒKƒ“ƒh‘I‘ð@HB‘I‘ði$ˆó‚̂݁j@i*ˆó‚̂݁j
‹óŠÔ[“U@‹…–_@‹…10“@‹…25“@‹…30“@‹…60“@ƒXƒeƒBƒbƒN@ƒXƒeƒBƒbƒNi‘¾j@j‹à@Á‹Ž
ƒAƒ~ƒmF@ChainF@CPKF@a@JmolF@RasmolF a ”ZÔ@”ZÂ@—΁@ƒsƒ“ƒN@”Zƒsƒ“ƒN@žò@Ž‡@Â
“œ½•Ê’…Fi#ˆó‚̂݁jFGalCGlcCManCFucCXylCSiaCGalNAcCGlcNAcCGlcA a Asn,Ser,Thr‘I‘ð b Asn@Ser@Thr
Ž_«E’†«E‰–Šî«‹æ•Ê@‹É«E”ñ‹É«‹æ•Ê@‘a…«ƒCƒ“ƒfƒbƒNƒX‡@I/O’l‡i“Á«Šî Rj@“™“d“_‡@ƒRƒ“ƒzƒ[ƒVƒ‡ƒ“‘I‘𐫁iƒ¿ƒwƒŠƒbƒNƒXEƒÀƒXƒgƒ‰ƒ“ƒhj
…‘fŒ‹‡•\Ž¦ b S-SŒ‹‡•\Ž¦@ b @@ b ”wŒiE•@ŠD@”’@®
@Chain‘I‘ðF A B C D E F G H I J K L M N O P Q R


  
m¶nƒlƒIƒ}ƒCƒVƒ“ineomycin BCƒAƒ~ƒmƒOƒŠƒRƒVƒhŒnj‚ªŒ‹‡‚µ‚½RNA 1ei2‚ÌPDBsumƒf[ƒ^
m‰EnDNAERNA‚̉–Šî•”•ª‚Ì—L‹@ŠT”O}



ƒÀ-ƒ‰ƒNƒ^ƒ€Œn^ƒyƒjƒVƒŠƒ“Œn‚̃yƒjƒVƒŠƒ“Gipenicillin Gj‚ªŒ‹‡‚µ‚½ƒyƒjƒVƒŠƒ“ƒAƒVƒ‰[ƒ[ 1fxv‚ÌChain B‚Æ‚»‚ÌPDBsumƒf[ƒ^


  
m¶E’†nƒIƒLƒTƒ]ƒŠƒWƒmƒ“Œn‚̃Šƒlƒ]ƒŠƒhilinezolidj‚ªŒ‹‡‚µ‚½‘½Ü”roƒgƒ‰ƒ“ƒXƒ|[ƒ^[AcrB 4k7q‚Æ‚»‚ÌPDBsumƒf[ƒ^
m‰EnƒŠƒlƒ]ƒŠƒh‚ªŒ‹‡‚µ‚½ƒŠƒ{ƒ\[ƒ€ƒTƒuƒ†ƒjƒbƒg 4wfa‚ÌChain X



ƒZƒtƒFƒ€Œn‚̃ZƒtƒBƒLƒVƒ€‚ªŒ‹‡‚µ‚½ƒAƒZƒ`ƒ‹ƒgƒ‰ƒ“ƒXƒtƒFƒ‰[ƒ[ 4kou‚Æ‚»‚ÌPDBsumƒf[ƒ^@¨ JmolƒgƒsƒbƒN



ƒeƒgƒ‰ƒTƒCƒNƒŠƒ“Œn‚̃Nƒƒ‹ƒeƒgƒ‰ƒTƒCƒNƒŠƒ“ichlortetracyclinej‚ƃCƒ\ƒNƒƒ‹ƒeƒgƒ‰ƒTƒCƒNƒŠƒ“iisochlortetracyclinej‚ªŒ‹‡‚µ‚½ƒeƒgƒ‰ƒTƒCƒNƒŠƒ“ƒŠƒvƒŒƒbƒT[iTetRj 4v2g‚Æ‚»‚ÌPDBsumƒf[ƒ^


ƒNƒƒ‹ƒeƒgƒ‰ƒTƒCƒNƒŠƒ“‚ÆU1Aƒ^ƒ“ƒpƒNŽ¿‚ªŒ‹‡‚µ‚½ƒeƒgƒ‰ƒTƒCƒNƒŠƒ“ƒAƒvƒ^ƒ}[ 3egz‚Æ‚»‚ÌPDBsumƒf[ƒ^



ƒŠƒ“ƒRƒ}ƒCƒVƒ“Œn‚̃Šƒ“ƒRƒ}ƒCƒVƒ“ilincomycinj‚ªŒ‹‡‚µ‚½ƒŠƒ“ƒRƒTƒ~ƒhŒnR¶•¨Ž¿ƒAƒfƒjƒŠƒ‹ƒgƒ‰ƒ“ƒXƒtƒFƒ‰[ƒ[LnuA 4wh5‚Æ‚»‚ÌPDBsumƒf[ƒ^



“œ½‡¬‘jŠQ–òƒ`ƒ…ƒjƒJƒ}ƒCƒVƒ“itunicamycinj‚ªŒ‹‡‚µ‚½ƒzƒXƒz-N-ƒAƒZƒ`ƒ‹ƒ€ƒ‰ƒ~ƒ‹ƒyƒ“ƒ^ƒyƒvƒ`ƒh“]ˆÚy‘fMraY 5jnq‚Æ‚»‚ÌPDBsumƒf[ƒ^
gMraY-antibiotic complex reveals details of tunicamycin mode of actionhiNature Chemical BiologyC2017/01/09j [NEW!]



V‹KR¶•¨Ž¿Œó•â‚Æ‚³‚ꂽƒvƒ‰ƒeƒ“ƒVƒ}ƒCƒVƒ“iplatensimycinj‚ªŒ‹‡‚µ‚½FabFƒ^ƒ“ƒpƒNŽ¿ 2gfx‚Æ‚»‚ÌPDBsumƒf[ƒ^
¦ƒvƒ‰ƒeƒ“ƒVƒ}ƒCƒVƒ“ŠÖ˜Aî•ñi‰½‚ê‚à2006-2007”NjF Nature b —L‹@‰»Šw”üpŠÙE•ªŠÙ b Chem-Station



ƒAƒ~ƒmƒkƒNƒŒƒIƒVƒhŒnR¶•¨Ž¿ƒsƒ…[ƒƒ}ƒCƒVƒ“ipuromycinj‚ªŒ‹‡‚µ‚½‘½Ü”roƒ|ƒ“ƒvAcrBZ 5nc5 [NEW!]@¨ JmolƒgƒsƒbƒN



ƒŠƒtƒ@ƒ“ƒsƒVƒ“irifampicinGƒŠƒtƒ@ƒ“ƒsƒ“Crifampinj‚ªŒ‹‡‚µ‚½RNAƒ|ƒŠƒƒ‰[ƒ[ 5uhg‚Æ‚»‚ÌPDBsumƒf[ƒ^ [NEW!]
¨ JmolƒgƒsƒbƒNiVR¶•¨Ž¿ƒVƒ…[ƒhƒEƒŠƒWƒ}ƒCƒVƒ“Ð‰îj


u¶ŠˆŠÂ‹«‰»Šw‚Ì•”‰®vƒz[ƒ€ƒy[ƒW b Jmol”Łu•ªŽq‚ÌŠwK’ v b Chime”Łu•ªŽq‚ÌŠwK’ v