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1hpx*qKNI-272iƒvƒƒeƒA[ƒ[‘jŠQÜjr
1hsgqƒCƒ“ƒWƒiƒrƒ‹^indinavir^IDViƒvƒƒeƒA[ƒ[‘jŠQÜjr
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1ohrqƒƒVƒ‹Ž_ƒlƒ‹ƒtƒBƒiƒrƒ‹^nelfinavir mesylate^NFViƒvƒƒeƒA[ƒ[‘jŠQÜjr
1rl8qƒŠƒgƒiƒrƒ‹^ritonavir^RTViƒvƒƒeƒA[ƒ[‘jŠQÜjr
2aqu*qƒAƒ^ƒUƒiƒrƒ‹^atazanavir^ATViƒvƒƒeƒA[ƒ[‘jŠQÜjGatazanavir‚͍Ā•W2Ží‚Ė‚Ī‚ŋA‚Ė‚݁r
2f8gqƒ_ƒ‹ƒiƒrƒ‹^darunabir^TMC-114iƒvƒƒeƒA[ƒ[‘jŠQÜjGTMC-114‚͍Ā•W2Ží‚Ė‚Ī‚ŋA‚Ė‚݁r
2fgvqƒTƒLƒiƒrƒ‹^saquinavir^SQViƒvƒƒeƒA[ƒ[‘jŠQÜjr
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2pk5qKNI-10075iƒvƒƒeƒA[ƒ[‘jŠQÜjGƒŠƒKƒ“ƒh‚͍Ā•W2Ží‚Ė‚Ī‚ŋA‚Ė‚݁r
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2pymqƒlƒ‹ƒtƒBƒiƒrƒ‹^nelfinavir^NFViƒvƒƒeƒA[ƒ[‘jŠQÜjr
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3a07iRHIVƒ^ƒ“ƒpƒNŽŋƒAƒNƒ`ƒmƒqƒrƒ“j@“ŊChain A
3bheqgthree armed pyrrolidine derivativehiƒvƒƒeƒA[ƒ[‘jŠQÜjr
3cywqƒ_ƒ‹ƒiƒrƒ‹^darunabir^TMC-114iƒvƒƒeƒA[ƒ[‘jŠQÜjGdarunavir‚Ļ‚æ‚Ņ‹ß–TƒAƒ~ƒmŽ_‚͍Ā•W2Ží‚Ė‚Ī‚ŋA‚Ė‚݁r
3dk1qGRL-0105AiƒvƒƒeƒA[ƒ[‘jŠQÜjGƒŠƒKƒ“ƒh‚͍Ā•W2Ží‚Ė‚Ī‚ŋA‚Ė‚݁r
3ekvqƒAƒ“ƒvƒŒƒiƒrƒ‹^amprenaviriƒvƒƒeƒA[ƒ[‘jŠQÜjr
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1t03‚ĖChain AEPETqƒeƒmƒzƒrƒ‹^tenofovir^TDFiŠjŽ_Œn‹t“]ŽĘy‘f‘jŠQÜjr
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1fk9‚ĖChain AqƒGƒtƒ@ƒrƒŒƒ“ƒc^efavirenz^EFVi”ņŠjŽ_Œn‹t“]ŽĘy‘f‘jŠQÜjr
1lwc‚ĖChain Aqƒlƒrƒ‰ƒsƒ“^nevirapine^NVPi”ņŠjŽ_Œn‹t“]ŽĘy‘f‘jŠQÜjr
2ic3*qHBY 097i”ņŠjŽ_Œn‹t“]ŽĘy‘f‘jŠQÜjr
2opp*qGW420867Xi”ņŠjŽ_Œn‹t“]ŽĘy‘f‘jŠQÜjr
2rkiq”ņŠjŽ_Œn‹t“]ŽĘy‘f‘jŠQÜr
2vg5*qƒ`ƒIƒJƒ‹ƒoƒ[ƒgŒn”ņŠjŽ_Œn‹t“]ŽĘy‘f‘jŠQÜr
2wonqUK-453061i”ņŠjŽ_Œn‹t“]ŽĘy‘f‘jŠQÜjr
2zd1qƒŠƒ‹ƒsƒrƒŠƒ“^ƒŠƒ‹ƒsƒ”ƒBƒŠƒ“^rilpivirine^TMC-278i”ņŠjŽ_Œn‹t“]ŽĘy‘f‘jŠQÜjr
3c6tq”ņŠjŽ_Œn‹t“]ŽĘy‘f‘jŠQÜr
3dleqGF128590i”ņŠjŽ_Œn‹t“]ŽĘy‘f‘jŠQÜjr
3dlgqGW564511i”ņŠjŽ_Œn‹t“]ŽĘy‘f‘jŠQÜjr
3dok*qGW678248i”ņŠjŽ_Œn‹t“]ŽĘy‘f‘jŠQÜjr
3dolqGW695634i”ņŠjŽ_Œn‹t“]ŽĘy‘f‘jŠQÜjr
3drpqMK-4965i”ņŠjŽ_Œn‹t“]ŽĘy‘f‘jŠQÜjr
3dyaqƒsƒ‰ƒ][ƒ‹Œni”ņŠjŽ_Œn‹t“]ŽĘy‘f‘jŠQÜjr
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1qs4‚ĖChain Aq5CITEPiƒCƒ“ƒeƒOƒ‰[ƒ[‘jŠQÜjriWebŽ‘—ŋ[PDF]ŽQÆj3l2t*qƒ‰ƒ‹ƒeƒOƒ‰ƒrƒ‹^raltegravir^MK-0518iƒCƒ“ƒeƒOƒ‰[ƒ[‘jŠQÜjGƒCƒ“ƒeƒOƒ‰[ƒ[‚̓vƒƒgƒ^ƒCƒv–A–—óƒEƒCƒ‹ƒX—R—ˆr
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œ‚ŧ‚Ė‘ž

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ƒAƒ~ƒmF@ChainF@CPKF@a@JmolF@RasmolF a ”ZÔ@—΁@”Zƒsƒ“ƒN@žō
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2i5j*qDHBNHi‹t“]ŽĘy‘f‚Ėˆę•”‚Å‚ ‚郊ƒ{ƒkƒNƒŒƒA[ƒ[H‘jŠQÜjr
4mbs‚ĖChain Aqƒ}ƒ‰ƒrƒƒN^maravirociƒPƒ‚ƒJƒCƒ“Žó—e‘ĖCCR5‘jŠQÜjr@“ŊPDBsumƒf[ƒ^ 4mbs_MRV$@MRViƒ}ƒ‰ƒrƒƒNj‘I‘ð@mCCR5 - WikipediaCMaraviroc - Wikipedian [NEW!GScientist‹LŽ–i2013/09/12jŽQÆ]

ŸƒOƒŠƒbƒhƒRƒ“ƒsƒ…[ƒeƒBƒ“ƒO‚É‚æ‚éHIVŠÖ˜AŽĄ—ÖōŒó•â’Tõ‚Å—p‚Ē‚į‚ę‚―ƒ^ƒ“ƒpƒNŽŋ
HIV-1 Protease s1a30t š
HIV Integrase s1hyvt š
HIV gp41 s1czqt š
HIV gp120 s1g9mt š

@š Find-a-Drug: Projects - HIViŒŧÝI—đGTeam Japan HIVCWorld Community Grid [“ú–{Œę”Å]ŽQÆj‚Å—p‚Ē‚į‚ę‚―ƒ^ƒ“ƒpƒNŽŋ

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1a8k‚ĖChain A-C kƒvƒƒeƒA[ƒ[l
1u04* kƒAƒ‹ƒSƒm[ƒgiargonautejl
1zlw# kR‘Ė2G12l
2bf1# kSIV—R—ˆ‚Ė”ņŒ‹‡Œ^gp120l
2cmr kgp41C’†˜aR‘Ėl
2exf‚ĖModel 1 kƒkƒNƒŒƒIƒJƒvƒVƒh NCp7CDNAl
2i5y‚ĖChain GEHELEM# kgp120CCD4l
2jzw‚ĖModel 1 kHIV-1CƒkƒNƒŒƒIƒJƒvƒVƒh NCp7C‹t“]ŽĘCDNAl
2nxy# kgp120CCD4CR‘Ė17bl
2oiy kRNAl
2qad# ƒXƒ‹ƒzƒ`ƒƒVƒ“iTysj‘I‘ð kHIV-1Cgp120CCD4CCCR5CR‘Ė412dl
2qsc*# kRHIV-1R‘ĖCgp120l
2rll ƒXƒ‹ƒzƒ`ƒƒVƒ“iTysj‘I‘ð kHIV-1CCCR5 N––’[l
3c3z* kHIV-1C“ņ–{―RNACƒŠƒ{ƒXƒ^ƒ}ƒCƒVƒ“iƒAƒ~ƒmƒOƒŠƒRƒVƒhŒnRķ•ĻŽŋjl
3c44* kHIV-1C“ņ–{―RNACƒpƒƒ‚ƒ}ƒCƒVƒ“iƒAƒ~ƒmƒOƒŠƒRƒVƒhŒnRķ•ĻŽŋjl
3c5d* kHIV-1C“ņ–{―RNACƒŠƒrƒhƒ}ƒCƒVƒ“iƒAƒ~ƒmƒOƒŠƒRƒVƒhŒnRķ•ĻŽŋjl
3c7r* kHIV-1C“ņ–{―RNACƒlƒIƒ}ƒCƒVƒ“iƒAƒ~ƒmƒOƒŠƒRƒVƒhŒnRķ•ĻŽŋjl
3dvv* kHIV-1ƒQƒmƒ€RNAC“ņ–{―RNACƒŠƒ{ƒXƒ^ƒ}ƒCƒVƒ“l
3gut k“]ŽĘˆöŽqp65iACEG―CƒqƒgjCNF-ƒČBiBDFH―CƒqƒgjCHIV-1 LTRiIJXY―jl


 HIV‚ƃGƒCƒY‚ĖÚŨî•ņ 



Ķ‚ą‚Ėƒy[ƒW‚ðgaritto‚ĖRSSƒŠ[ƒ_[‚ÅŒĐ‚é
Ķ‚ą‚Ėƒy[ƒW‚ð‚Í‚Ä‚ČƒAƒ“ƒeƒi‚É’Į‰Á‚·‚é



RHIV–ōƒlƒ‹ƒtƒBƒiƒrƒ‹‚ðŠÜ‚ÞPDBsumƒf[ƒ^1ohr‚æ‚č


  
‘jŠQÜKNI-272Œ‹‡HIV-1ƒvƒƒeƒA[ƒ[‚Ė’†ŦŽq\‘Ē‰ðÍƒf[ƒ^2zye
kķãl‘S‘Ė\‘ĒCkķ‰šlPDBsumƒf[ƒ^2zye_KNI‚ÉHEDŒīŽq’Į‰ÁiƒgƒsƒbƒNƒX•ŠŽq‚ÅŽQÆ‰ÂjCk‰El‰š‹LŽ‘—ŋ}2‚ĖŠY“–•”•Š
Ķ“ú–{ŒīŽq—ÍŒĪ‹†ŠJ”­‹@\FƒvƒŒƒX”­•\i2009/05/10jŽQÆ




ƒOƒ‰ƒt‚P@‘“ā‚É‚Ļ‚Ŋ‚éHIVŠīõŽŌ”‚Ė„ˆÚi”N—îŠK‹‰•Ęj
Ķƒf[ƒ^ˆø—pF
•―Ž16”NƒGƒCƒY”­ķ“ŪŒü”N•ņiŒúķ˜J“­ČC2005/04/25j^Excelƒf[ƒ^
ĶÅVƒf[ƒ^F•―Ž20i2008j”NƒGƒCƒY”­ķ“ŪŒü”N•ņiƒGƒCƒY“ŪŒüˆÏˆõ‰ïC2009/06/17j a •―Ž18”N”N•ņb2009/02/18”Åxlsƒf[ƒ^
Ķ‘žƒTƒCƒg‚ĖƒOƒ‰ƒt—áiŽÐ‰ïŽĀîƒf[ƒ^}˜^‚æ‚čjFĒŠE‚Ėó‹ĩCHIVŠīõŽŌEƒGƒCƒYŠģŽŌ•ņ”„ˆÚC“s“đ•{Œ§•ĘHIVŠīõŽŌEƒGƒCƒYŠģŽŌ”i2004”Nj


ŽQl@‘―Ü•đ—p—Ö@iHAARTj‚Ė—á Ļ Jmol”Ł^ƒGƒCƒY–ō‚Ė—á
Ķ‹gŠJ‘ŨM •ŌCuƒEƒCƒ‹ƒXEŨ‹Û‚ÆŠīõĮ‚Š‚í‚Đ‚évCp.102C—r“yŽÐ(2004)
Ķ‰æ‘œ‚͍RHIV–ōî•ņiHIV^AIDSæ’[ˆã—ÊJ”­ƒZƒ“ƒ^[j‚æ‚č
—á‚P —á‚Q

AZT{3TC{EFV

AZT{3TC{NFV


•\‚P@1970”N‘ãˆČ~‚ɏoŒŧ‚ĩ‚―Žå‚ȐV‹ŧŠīõĮ
ĶˆČ‰š‚Ė•ķŒĢ‚Đ‚įŽå—v•”•Š‚ð”ēˆ‚ĩ‚Ä•ŌW
ŠīõĮF’|“c”ü•ķE‰Š•”M•FC
uSARS‚͉―‚ðŒx‚ĩ‚Ä‚Ē‚é‚Ė‚ЁvCŠâ”gƒuƒbƒNƒŒƒbƒg(2003)
”N V‹ŧŠīõĮ
•aŒī”ũķ•Ļ Ží—Þ Žū•a
 1973  ƒƒ^ƒEƒCƒ‹ƒX ƒEƒCƒ‹ƒX ŽŽ™‚Ė‰š—Ÿ
1977 ƒGƒ{ƒ‰ƒEƒCƒ‹ƒX ƒEƒCƒ‹ƒX ƒGƒ{ƒ‰oŒŒ”M
1977 Legionella pneumophila Ũ‹Û ƒŒƒWƒIƒlƒ‰ĮiÝ‹―ŒRl•aj
1977 ƒnƒ“ƒ^ƒEƒCƒ‹ƒX ƒEƒCƒ‹ƒX tĮŒóŦoŒŒ”M
1980 HTLV-I ƒEƒCƒ‹ƒX ŽlTŨ–E”’ŒŒ•a
1982 •aŒīŦ‘å’°‹ÛO157FH7 Ũ‹Û oŒŒŦ‘å’°‰ŠC—nŒŒŦ”A“ŏĮĮŒōŒQ
1983 HIV ƒEƒCƒ‹ƒX ƒGƒCƒY
1983 Helicobacter pylori Ũ‹Û ˆÝ’Ũá‡
1988 EŒ^ŠĖ‰ŠƒEƒCƒ‹ƒX ƒEƒCƒ‹ƒX EŒ^ŠĖ‰Š
1989 CŒ^ŠĖ‰ŠƒEƒCƒ‹ƒX ƒEƒCƒ‹ƒX CŒ^ŠĖ‰Š
1992 Vibrio cholerae O139 Ũ‹Û ƒRƒŒƒ‰
1996 ‹ŠC–ȏó”]ĮƒvƒŠƒIƒ“ ƒvƒŠƒIƒ“iƒ^ƒ“ƒpƒNŽŋj •ÏˆŲŒ^ƒNƒƒCƒcƒtƒFƒ‹ƒgEƒ„ƒRƒu•a
1997 ƒgƒŠŒ^ƒCƒ“ƒtƒ‹ƒGƒ“ƒUƒEƒCƒ‹ƒX ƒEƒCƒ‹ƒX ƒCƒ“ƒtƒ‹ƒGƒ“ƒU
1998 ƒjƒpƒEƒCƒ‹ƒX ƒEƒCƒ‹ƒX ”]‰Š
2002 SARSƒRƒƒiƒEƒCƒ‹ƒX ƒEƒCƒ‹ƒX ”x‰Š
2004 ƒgƒŠŒ^ƒCƒ“ƒtƒ‹ƒGƒ“ƒUƒEƒCƒ‹ƒX ƒEƒCƒ‹ƒX ƒCƒ“ƒtƒ‹ƒGƒ“ƒU


•\‚Q@‚Ē‚ë‚Ē‚ë‚ČƒEƒCƒ‹ƒXiDNAƒEƒCƒ‹ƒX‚ÆRNAƒEƒCƒ‹ƒXj
ĶˆČ‰š‚ð•ŌWF‹gŠJ‘ŨM •ŌC
uƒEƒCƒ‹ƒXEŨ‹Û‚ÆŠīõĮ‚Š‚í‚Đ‚évCp.37C—r“yŽÐ(2004)
  •Š—Þ —á
Žå‚ČDNAƒEƒCƒ‹ƒX ƒ|ƒbƒNƒXƒEƒCƒ‹ƒX‰Č  
ƒwƒ‹ƒyƒXƒEƒCƒ‹ƒX‰Č ĶŒïƒwƒ‹ƒyƒX
ƒAƒfƒmƒEƒCƒ‹ƒX‰Č  
ƒpƒsƒ[ƒ}ƒEƒCƒ‹ƒX‰Č
iƒ|ƒŠƒI[ƒ}ƒEƒCƒ‹ƒX‰Č‚ā“Ž—j
Žq‹{čō‚Š‚ņ
ƒwƒpƒhƒiƒEƒCƒ‹ƒX‰Č # BŒ^ŠĖ‰Š
ƒpƒ|ƒoƒEƒCƒ‹ƒX‰Č  
Žå‚ČRNAƒEƒCƒ‹ƒX ƒpƒ‰ƒ~ƒNƒ\ƒEƒCƒ‹ƒX‰Č –ƒ]
ƒIƒ‹ƒgƒ~ƒNƒ\ƒEƒCƒ‹ƒX‰Č
iƒIƒ‹ƒ\ƒ~ƒNƒ\ƒEƒCƒ‹ƒX‰Čj
ƒCƒ“ƒtƒ‹ƒGƒ“ƒU
ƒRƒƒiƒEƒCƒ‹ƒX‰Č SARS
ƒAƒŒƒiƒEƒCƒ‹ƒX‰Č ƒ‰ƒbƒT”M
ƒŒƒgƒƒEƒCƒ‹ƒX‰Č # AIDS
ƒtƒBƒƒEƒCƒ‹ƒX‰Č  
ƒŒƒIƒEƒCƒ‹ƒX‰Č ƒƒ^
ƒsƒRƒ‹ƒiƒEƒCƒ‹ƒX‰Č ƒ|ƒŠƒICAŒ^ŠĖ‰Š
ƒJƒŠƒVƒEƒCƒ‹ƒX‰Č ƒmƒ
ƒ‰ƒuƒhƒEƒCƒ‹ƒX‰Č ‹ķŒĒ•a
ƒtƒ‰ƒrƒEƒCƒ‹ƒX‰Č
iƒgƒKƒEƒCƒ‹ƒX‰Č‚ā“Ž—j
“ú–{”]‰ŠCƒEƒGƒXƒgƒiƒCƒ‹”MCƒfƒ“ƒO”MCCŒ^ŠĖ‰Š
Ķ“؃RƒŒƒ‰
ƒuƒjƒ„ƒEƒCƒ‹ƒX‰Č  

# Å‹ß‚ĖICTVƒŒƒ|[ƒg‚ł́CƒwƒpƒhƒiƒEƒCƒ‹ƒX‰Č‚ƃŒƒgƒƒEƒCƒ‹ƒX‰Č‚́Cw‹t“]ŽĘ‚ðs‚ĪDNA‚Ļ‚æ‚ŅRNAƒEƒCƒ‹ƒXx‚Æ‚ĩ‚Ä“Ŋ‚ķƒJƒeƒSƒŠ‚É•Š—Þ‚ģ‚ę‚Ä‚Ē‚éB




Kawakami Model
ŠJ”­‚Ėėã Ÿæķ‚Đ‚į‚Ē‚―‚ū‚Ē‚―3DƒvƒŠƒ“ƒ^–ÍŒ^‚ÆJmol‰æ‘œ
iėã‚ģ‚ņ‚ĖŠY“–ƒcƒC[ƒgj


uķŠˆŠÂ‹Ŧ‰ŧŠw‚Ė•”‰Ūvƒz[ƒ€ƒy[ƒW b Jmol”Łu•ŠŽq‚ĖŠwK’ v