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  1. “ú–{ŠC‚Ėķ•Ļ‚Ɗ‹Ŧ - uķ•Ļ‚Ė‰ČŠw@ˆâ“`v2018”N1†i–{ƒTƒCƒgj

      
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    ƒAƒ~ƒmŽ_‚Ļ‚æ‚Ņ“ÁŦŠî‚Ėe…ŦE‘a…Ŧ b Log P‚ðƒ|ƒPƒbƒg‚ɁI


  2. RCSB PDB 2017/12/27 V‹KŒöŠJƒf[ƒ^‚æ‚čF5wi3 Structure of Acinetobacter baumannii carbapenemase OXA-239 K82D bound to cefotaxime@ĶƒZƒtƒHƒ^ƒLƒVƒ€Œ‹‡B‘ž‚É5wi7iƒhƒŠƒyƒlƒ€Œ‹‡jC5wibiƒCƒ~ƒyƒlƒ€Œ‹‡jB

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  3. ĄŒŽ‚Ė•ŠŽq 217: ƒIƒsƒIƒCƒhŽó—e‘ĖiOpioid ReceptorsjiPDBjC2018/01j b Molecule of the MonthiPDBj

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    mOpioid receptor - Wikipedian
    4dkl*iƒĘƒIƒsƒIƒCƒhŽó—e‘Ėj@ƒŠƒKƒ“ƒhBF0iƒAƒ“ƒ^ƒSƒjƒXƒgj‘I‘ð@“ŊPDBsumƒf[ƒ^4dkl_BF0$@mƒĘ-opioid receptor - Wikipedian
    4djh*%iƒČƒIƒsƒIƒCƒhŽó—e‘Ėj@“ŊChain A@ƒŠƒKƒ“ƒhJDCiJDTicj‘I‘ð@“ŊPDBsumƒf[ƒ^4djh_JDC$@mƒČ-opioid receptor - Wikipedian
    4ej4iƒÂƒIƒsƒIƒCƒhŽó—e‘Ėj@ƒŠƒKƒ“ƒhEJ4iƒiƒ‹ƒgƒŠƒ“ƒh[ƒ‹j‘I‘ð@“ŊPDBsumƒf[ƒ^4ej4_EJ4$@mƒÂ-opioid receptor - Wikipedian
    4ea3*%iƒmƒVƒZƒvƒ`ƒ“/ƒIƒ‹ƒtƒ@ƒjƒ“FQiN/OFQjŽó—e‘ĖGnociception opioid (NOP) receptorj@“ŊChain A@ƒŠƒKƒ“ƒh0NN‘I‘ð@PDBsumƒf[ƒ^i0NNCA―j$@mNociceptin receptor - Wikipedian

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  4. RCSB PDB 2018/01/03 V‹KŒöŠJƒf[ƒ^‚æ‚čF6elq Carbon Monoxide Dehydrogenase IV from Carboxydothermus hydrogenoformans

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  5. ƒAƒ‹ƒcƒnƒCƒ}[•a•aˆö•ĻŽŋ‚ð’áŒļ‚ģ‚đ‚éŠų‘ķ–ōƒJƒNƒeƒ‹‚Ė“Ŋ’č@|ŠģŽŌ—R—ˆiPSŨ–E‚ð—p‚Ē‚―‰ŧ‡•ĻƒXƒNƒŠ[ƒjƒ“ƒO‚Æin vitroƒgƒ‰ƒCƒAƒ‹|i‹ž“s‘åŠwC2017/11/28j

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    ƒuƒƒ‚ƒNƒŠƒvƒ`ƒ“ibromocriptinej@mBromocriptine - Wikipedian a Ķƒuƒƒ‚ƒNƒŠƒvƒ`ƒ“Œ‹‡PDBƒf[ƒ^—áF 5vcgiƒVƒgƒNƒƒ€P450 3A4j@08Yiƒuƒƒ‚ƒNƒŠƒvƒ`ƒ“j‘I‘ð@“ŊPDBsumƒf[ƒ^5vcg_08Y$
    ƒNƒƒ‚ƒŠƒ“icromolynj@mCromoglicic acid - Wikipedian
    ƒgƒsƒ‰ƒ}[ƒgitopiramatej@mTopiramate - Wikipedian a Ķƒgƒsƒ‰ƒ}[ƒgŒ‹‡PDBƒf[ƒ^—áF 5jna‚ĖChain Ai’YŽ_’E…y‘fIVj@TORiƒgƒsƒ‰ƒ}[ƒgj‘I‘ð@“ŊPDBsumƒf[ƒ^5jna_TOR$
    ƒuƒƒ‚ƒNƒŠƒvƒ`ƒ“CƒNƒƒ‚ƒŠƒ“Cƒgƒsƒ‰ƒ}[ƒg‚Ė“ŊŽž•\ŽĶ

    ƒoƒbƒNƒ{[ƒ“@“ņŽŸ\‘Ē
    DNA/RNAiATGCUCbackbonej
    ‘S‘I‘ð@ƒ^ƒ“ƒpƒNŽŋ‘I‘ð@DNA/RNA‘I‘ð@“Ŋbackbone‘I‘ð@ƒŠƒKƒ“ƒh‘I‘ð@HB‘I‘ði$ˆó‚Ė‚݁j
    ‹óŠÔ[“U@‹…–_@‹…60“@ƒXƒeƒBƒbƒN@j‹ā@Á‹Ž
    ƒAƒ~ƒmF@ChainF@CPKF@a@JmolF@RasmolF

    Ž_ŦE’†ŦE‰–ŠîŦ‹æ•Ę@‹ÉŦE”ņ‹ÉŦ‹æ•Ę
    ‘a…ŦƒCƒ“ƒfƒbƒNƒX‡@I/O’l‡i“ÁŦŠî Rj@“™“d“_‡
    ƒRƒ“ƒzƒ[ƒVƒ‡ƒ“‘I‘ðŦiƒŋƒwƒŠƒbƒNƒXEƒĀƒXƒgƒ‰ƒ“ƒhj
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    mķnƒuƒƒ‚ƒNƒŠƒvƒ`ƒ“ibromocriptinejCƒNƒƒ‚ƒŠƒ“icromolynjCƒgƒsƒ‰ƒ}[ƒgitopiramatej@m’†E‰Enƒuƒƒ‚ƒNƒŠƒvƒ`ƒ“Œ‹‡5vcg‚ƃgƒsƒ‰ƒ}[ƒgŒ‹‡5jnaiChain AjC‚Ļ‚æ‚ŅŠePDBsumƒf[ƒ^


  6. “ú–{ŽYƒnƒiƒKƒTƒNƒ‰ƒQ‚æ‚čŠJ”­I‘ÏŽ_Ŧ—ΐFŒuŒõƒ^ƒ“ƒpƒNŽŋGamillus@`ķ‘Ė“ā‚ĖŽ_ŦŠÂ‹Ŧ‚ð’ēļ‚·‚éV‹Zp`iJSTC2017/12/29j@Ķ5y00E5y01i2018/01/17ŒöŠJƒf[ƒ^j

    PDBƒf[ƒ^ 5y00iƒnƒiƒKƒTƒNƒ‰ƒQ‚Ė—ΐF‚ĖŒuŒõƒ^ƒ“ƒpƒNŽŋGamillusGfluorescence (ON) statej
    5y00iƒnƒiƒKƒTƒNƒ‰ƒQ‚Ė—ΐF‚ĖŒuŒõƒ^ƒ“ƒpƒNŽŋGamillusGfluorescence (ON) statej@@CRQiŒuŒõ’cGGln-Tyr-Glyj‘I‘ð
    ĶƒIƒƒ“ƒNƒ‰ƒQ‚ĖGFP‚Ė—áF 1hcj‚ĖChain AiGFPj@ŒuŒõ”­ķ•”•Š‚ĖF•Š‚ŊiÔF”­F’cCÂFPheC—΁FValC…FFGlnj@“ŊŒīŽq’c‚Ė‘I‘ð@”­F’c‹Ī–ð“ņdŒ‹‡‚ðƒsƒ“ƒN•\ŽĶ@Ļ —ΐFŒuŒõ‚ð”­‚·‚éƒ^ƒ“ƒpƒNŽŋ^GFP

    ƒoƒbƒNƒ{[ƒ“@“ņŽŸ\‘Ē
    ‘S‘I‘ð@ƒ^ƒ“ƒpƒNŽŋ‘I‘ð@ƒŠƒKƒ“ƒh‘I‘ð
    ‹óŠÔ[“U@‹…–_@‹…60“@ƒXƒeƒBƒbƒN@j‹ā@Á‹Ž
    ƒAƒ~ƒmF@ChainF@CPKF@a@JmolF@RasmolF

    Ž_ŦE’†ŦE‰–ŠîŦ‹æ•Ę@‹ÉŦE”ņ‹ÉŦ‹æ•Ę
    ‘a…ŦƒCƒ“ƒfƒbƒNƒX‡@I/O’l‡i“ÁŦŠî Rj@“™“d“_‡
    ƒRƒ“ƒzƒ[ƒVƒ‡ƒ“‘I‘ðŦiƒŋƒwƒŠƒbƒNƒXEƒĀƒXƒgƒ‰ƒ“ƒhj
    …‘fŒ‹‡•\ŽĶ
    @
    @@
    ”wŒiE•@ŠD@”’@Ū

      
    mķnƒnƒiƒKƒTƒNƒ‰ƒQ‚Ė—ΐF‚ĖŒuŒõƒ^ƒ“ƒpƒNŽŋGamillus 5y00ifluorescence (ON) statej@m‰EnƒIƒƒ“ƒNƒ‰ƒQ‚ĖGFP‚Ė—á 1hcj‚ĖChain A


  7. RCSB PDB 2018/01/24 V‹KŒöŠJƒf[ƒ^‚æ‚čF5ybo Fe(II)/(alpha)ketoglutarate-dependent dioxygenase PrhA in complex with preaustinoid A1@Ķ‘ž‚É5yblE5ybmE5ybpipreaustinoid A1Œ‹‡jE5ybqipreaustinoid A2Œ‹‡jE5ybripreaustinoid A3Œ‹‡jE5ybsiberkeleyone AŒ‹‡jE5ybti“ŊjB

    PDBƒf[ƒ^ 5ybo‚ĖChain BiƒvƒŒƒAƒEƒXƒ`ƒmƒCƒhA1‚ŠŒ‹‡‚ĩ‚―”ņƒwƒ€“SFe(II)/ƒŋ]ƒPƒgƒOƒ‹ƒ^ƒ‹Ž_ˆË‘ķŦƒWƒIƒLƒVƒQƒi[ƒ[PrhAj
    5ybo‚ĖChain BiƒvƒŒƒAƒEƒXƒ`ƒmƒCƒhA1‚ŠŒ‹‡‚ĩ‚―”ņƒwƒ€“SFe(II)/ƒŋ]ƒPƒgƒOƒ‹ƒ^ƒ‹Ž_ˆË‘ķŦƒWƒIƒLƒVƒQƒi[ƒ[PrhAj@“ŊPDBsumƒf[ƒ^5ybo_8SX$@8SXiƒvƒŒƒAƒEƒXƒ`ƒmƒCƒhA1j‘I‘ð
    PDBsumƒf[ƒ^5ybp_8SX$iƒvƒŒƒAƒEƒXƒ`ƒmƒCƒhA1‚ŠŒ‹‡‚ĩ‚―PrhAj
    PDBsumƒf[ƒ^5ybq_8T0$iƒvƒŒƒAƒEƒXƒ`ƒmƒCƒhA2‚ŠŒ‹‡‚ĩ‚―PrhAj@8T0iƒvƒŒƒAƒEƒXƒ`ƒmƒCƒhA2j‘I‘ð
    PDBsumƒf[ƒ^5ybr_8T9$iƒvƒŒƒAƒEƒXƒ`ƒmƒCƒhA3‚ŠŒ‹‡‚ĩ‚―PrhAj@8T9iƒvƒŒƒAƒEƒXƒ`ƒmƒCƒhA3j‘I‘ð
    PDBsumƒf[ƒ^5ybs_8TC$iberkeleyone A‚ŠŒ‹‡‚ĩ‚―PrhAj@8TCiberkeleyone Aj‘I‘ð
    PDBsumƒf[ƒ^5ybt_8TC$i“Ŋãj

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    ‘S‘I‘ð@ƒ^ƒ“ƒpƒNŽŋ‘I‘ð@ƒŠƒKƒ“ƒh‘I‘ð
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    ƒAƒ~ƒmF@ChainF@CPKF@a@JmolF@RasmolF

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    ‘a…ŦƒCƒ“ƒfƒbƒNƒX‡@I/O’l‡i“ÁŦŠî Rj@“™“d“_‡
    ƒRƒ“ƒzƒ[ƒVƒ‡ƒ“‘I‘ðŦiƒŋƒwƒŠƒbƒNƒXEƒĀƒXƒgƒ‰ƒ“ƒhj
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    mķnƒvƒŒƒAƒEƒXƒ`ƒmƒCƒhA1‚ŠŒ‹‡‚ĩ‚―”ņƒwƒ€“SFe(II)/ƒŋ]ƒPƒgƒOƒ‹ƒ^ƒ‹Ž_ˆË‘ķŦƒWƒIƒLƒVƒQƒi[ƒ[PrhA 5ybo‚ĖChain B
    m‰En5yboE5ybpipreaustinoid A1Œ‹‡jC5ybqipreaustinoid A2Œ‹‡jC5ybripreaustinoid A3Œ‹‡jC5ybsE5ybtiberkeleyone AŒ‹‡j‚ĖPDBsumƒf[ƒ^


  8. ĄŒŽ‚Ė•ŠŽq 218: EPSP‡Žy‘f‚Əœ‘ÜiEPSP Synthase and WeedkillersjiPDBjC2018/02j b Molecule of the MonthiPDBj

    PDBƒf[ƒ^ 2ggaiƒOƒŠƒzƒT[ƒg‚ŠŒ‹‡‚ĩ‚―EPSP‡Žy‘fj
    mEPSP synthase - WikipediaCGlyphosate - Wikipedian
    2ggaiƒĘƒIƒsƒIƒCƒhŽó—e‘Ėj@GPJiƒOƒŠƒzƒT[ƒgj‘I‘ð@“ŊPDBsumƒf[ƒ^2gga_GPJ$
    ƒOƒŠƒzƒT[ƒgiglyphosatej
    2,4-D

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    ‘S‘I‘ð@ƒ^ƒ“ƒpƒNŽŋ‘I‘ð@ƒŠƒKƒ“ƒh‘I‘ð@HB‘I‘ði$ˆó‚Ė‚݁j
    ‹óŠÔ[“U@‹…–_@‹…60“@ƒXƒeƒBƒbƒN@j‹ā
    ƒAƒ~ƒmF@ChainF@CPKF@a@JmolF@RasmolF

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  9. Structural basis for DNMT3A-mediated de novo DNA methylationiNatureC2018/01/17j@Ķ5yx2i2018/01/31ŒöŠJƒf[ƒ^G‘ž‚É6brrE6f57j

    PDBƒf[ƒ^ 5yx2i2‚‚ĖCpGƒTƒCƒg‚ðŠÜ‚ÞDNA‚ÆDNMT3A-DNMT3L‚Ė•Ą‡‘Ėj
    5yx2i2‚‚ĖCpGƒTƒCƒg‚ðŠÜ‚ÞDNA‚ÆDNMT3A-DNMT3L‚Ė•Ą‡‘Ėj@SAHiS-ƒAƒfƒmƒVƒ‹ƒzƒ‚ƒVƒXƒeƒCƒ“j‘I‘ð@PYOiRNAƒŠƒ“ƒLƒ“ƒOj‘I‘ð

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    ‘S‘I‘ð@ƒ^ƒ“ƒpƒNŽŋ‘I‘ð@ƒŠƒKƒ“ƒh‘I‘ð@DNA/RNA‘I‘ð@DNA‘I‘ð@DNA/RNA‰–Šî‘I‘ð@DNA/RNA backbone‘I‘ð
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    ƒAƒ~ƒmF@ChainF@CPKF@a@JmolF@RasmolF

    Ž_ŦE’†ŦE‰–ŠîŦ‹æ•Ę@‹ÉŦE”ņ‹ÉŦ‹æ•Ę
    ‘a…ŦƒCƒ“ƒfƒbƒNƒX‡@I/O’l‡i“ÁŦŠî Rj@“™“d“_‡
    ƒRƒ“ƒzƒ[ƒVƒ‡ƒ“‘I‘ðŦiƒŋƒwƒŠƒbƒNƒXEƒĀƒXƒgƒ‰ƒ“ƒhj
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    2‚‚ĖCpGƒTƒCƒg‚ðŠÜ‚ÞDNA‚ÆDNMT3A-DNMT3L‚Ė•Ą‡‘Ė 5yx2


  10. Structures of the prefusion form of measles virus fusion protein in complex with inhibitorsiPNASC2018/02/20j@Ķ2018/02/21ŒöŠJƒf[ƒ^5yxwi–Œ—Z‡ƒ^ƒ“ƒpƒNŽŋjE5yzci‘jŠQ‰ŧ‡•ĻAS-48Œ‹‡G‰šŒfjE5yzdi‘jŠQƒyƒvƒ`ƒhFIPŒ‹‡j

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    ‹óŠÔ[“U@‹…–_@‹…60“@ƒXƒeƒBƒbƒN@j‹ā@Á‹Ž
    ƒAƒ~ƒmF@ChainF@CPKF@a@JmolF@RasmolF

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